Hydrochloric Acid → HCID 89644270, compound

HRID 1746844Notes

Reaction equation

HRID 1746844 reaction equation
[CH3:1][O:2][C:3](=[O:55])[C@H:4]([N:41]1[CH2:45][CH2:44][C@H:43]([NH:46]C(OC(C)(C)C)=O)[C:42]1=[O:54])[CH2:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:16][C:17]([F:20])([F:19])[F:18])[C:12]([NH:21]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[N:11][CH:10]=[CH:9]2.[ClH:56]>C(Cl)Cl>[ClH:56].[ClH:56].[CH3:1][O:2][C:3](=[O:55])[C@H:4]([N:41]1[CH2:45][CH2:44][C@H:43]([NH2:46])[C:42]1=[O:54])[CH2:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:16][C:17]([F:19])([F:20])[F:18])[C:12]([NH2:21])=[N:11][CH:10]=[CH:9]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89644341HCID 89644341, compound

Product 1

HCID 89644270HCID 89644270, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 1.09 g (1.45 mmol) of (R)-2-((S)-3-tert-Butoxycarbonylamino-2-oxo-pyrrolidin-1-yl)-3-[7-trifluoromethoxy-1-(trityl-amino)-isoquinolin-6-yl]-propionic acid methyl ester, dissolved in 6 ml abs. CH2Cl2, 1.7 ml (6 eq) etheric HCl-solution are added at 0° C. The reaction mixture is stirred for 3 h at this temperature. After warming up to r.t., the solid product is isolated by filtration: 588 mg are obtained.

Workup

  1. customthe solid product is isolated by filtration
  2. custom588 mg are obtained

Sources & evidence

ORD record
ord-4d4138d271994677b89f57cd80e9d9a5
Source dataset
uspto-grants-2015_10
Patent number
US09150544B2

Reaction notes

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