Diisopropylethylamine → HCID 71626218, compound

HRID 1746845Notes

Reaction equation

HRID 1746845 reaction equation
Cl.Cl.[CH3:3][O:4][C:5](=[O:31])[C@H:6]([N:24]1[CH2:28][CH2:27][C@H:26]([NH2:29])[C:25]1=[O:30])[CH2:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][C:17]=1[O:18][C:19]([F:22])([F:21])[F:20])[C:14]([NH2:23])=[N:13][CH:12]=[CH:11]2.C(N(C(C)C)CC)(C)C.[N:41]1([C:46]2[S:47][C:48]([S:51](Cl)(=[O:53])=[O:52])=[CH:49][N:50]=2)[CH2:45][CH2:44][CH2:43][CH2:42]1>C(Cl)Cl>[CH3:3][O:4][C:5](=[O:31])[C@H:6]([N:24]1[CH2:28][CH2:27][C@H:26]([NH:29][S:51]([C:48]2[S:47][C:46]([N:41]3[CH2:45][CH2:44][CH2:43][CH2:42]3)=[N:50][CH:49]=2)(=[O:53])=[O:52])[C:25]1=[O:30])[CH2:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][C:17]=1[O:18][C:19]([F:21])([F:22])[F:20])[C:14]([NH2:23])=[N:13][CH:12]=[CH:11]2

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 89644270HCID 89644270, compoundHCID 89644455HCID 89644455, compound

Product 1

HCID 71626218HCID 71626218, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a suspension of 485 mg (1 mmol) of (R)-3-(1-Amino-7-trifluoromethoxy-isoquinolin-6-yl)-2-((S)-3-amino-2-oxo-pyrrolidin-1-yl)-propionic acid methyl ester bishydrochloride in 6 ml CH2Cl2, 873 μl (5 mmol) diisopropylethylamine and 379 mg (1.5 mmol) 2-Pyrrolidin-1-yl-thiazole-5-sulfonyl chloride, dissolved in 5 ml CH2Cl2, are added subsequently at 0° C. under stirring.

Workup

  1. additionare added subsequently at 0° C.

Sources & evidence

ORD record
ord-055c153067794dbc994cd4a8039d8354
Source dataset
uspto-grants-2015_10
Patent number
US09150544B2

Reaction notes

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