1-Propanol → HCID 89644261, compound

HRID 1746846Notes

Reaction equation

HRID 1746846 reaction equation
[CH3:1][O:2][C:3](=[O:42])[C@H:4]([N:22]1[CH2:26][CH2:25][C@H:24]([NH:27][S:28]([C:31]2[S:35][C:34]([N:36]3[CH2:40][CH2:39][CH2:38][CH2:37]3)=[N:33][CH:32]=2)(=[O:30])=[O:29])[C:23]1=[O:41])[CH2:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:16][C:17]([F:20])([F:19])[F:18])[C:12]([NH2:21])=[N:11][CH:10]=[CH:9]2.[CH2:43](O)[CH2:44]C>[Ti+4].CC(C)[O-]>[CH2:1]([O:2][C:3](=[O:42])[C@H:4]([N:22]1[CH2:26][CH2:25][C@H:24]([NH:27][S:28]([C:31]2[S:35][C:34]([N:36]3[CH2:37][CH2:38][CH2:39][CH2:40]3)=[N:33][CH:32]=2)(=[O:29])=[O:30])[C:23]1=[O:41])[CH2:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:16][C:17]([F:18])([F:19])[F:20])[C:12]([NH2:21])=[N:11][CH:10]=[CH:9]2)[CH2:43][CH3:44]

Participants

4

Reactant 2

HCID 10311-PropanolHCID 71626218HCID 71626218, compound

Product 1

HCID 89644261HCID 89644261, compound

Reagents, catalysts & solvents 1

HCID 131726488HCID 131726488, compoundCatalyst

Procedure

To 57 mg (91 μmol) (R)-3-(1-Amino-7-trifluoromethoxy-isoquinolin-6-yl)-2-[(S)-2-oxo-3-(2-pyrrolidin-1-yl-thiazole-5-sulfonylamino)-pyrrolidin-1-yl]-propionic acid methyl ester in 2 ml 1-propanol, 64.4 mg (227 μmol, 2.5 eq) titanium(IV)-isopropoxide are added.

Sources & evidence

ORD record
ord-343061110cb74b0ba9187d095a30da96
Source dataset
uspto-grants-2015_10
Patent number
US09150544B2

Reaction notes

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