Hydrochloric Acid → HCID 89851554, compound

HRID 1746918Notes

Reaction equation

HRID 1746918 reaction equation
[NH2:1][C:2](=[O:38])[C:3](=[O:37])[CH:4]([NH:12][C:13]([C:15]1[C:16]([N:21]2[CH:29]=[C:28]3[C:23]([CH2:24][N:25](C(OC(C)(C)C)=O)[CH2:26][CH2:27]3)=[N:22]2)=[N:17][CH:18]=[CH:19][CH:20]=1)=[O:14])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[ClH:39]>O1CCOCC1>[ClH:39].[NH2:1][C:2](=[O:38])[C:3](=[O:37])[CH:4]([NH:12][C:13](=[O:14])[C:15]1[CH:20]=[CH:19][CH:18]=[N:17][C:16]=1[N:21]1[CH:29]=[C:28]2[C:23]([CH2:24][NH:25][CH2:26][CH2:27]2)=[N:22]1)[CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71768810HCID 71768810, compound

Product 1

HCID 89851554HCID 89851554, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of tert-butyl 2-(3-(4-amino-3,4-dioxo-1-phenylbutan-2-ylcarbamoyl)pyridin-2-yl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylate in dioxane (5 ml) 400 μL of 4M HCl in dioxane were added and stirred over night at room temperature. The mixture then was concentrated, and the remainder purified by chromatography over Chromabond RP-C18 (eluent: water/acetonitrile) to give 24 mg of the title compound; ESI-MS [M+H]+: 419.2.

Workup

  1. concentrationThe mixture then was concentrated
  2. customthe remainder purified by chromatography over Chromabond

Sources & evidence

ORD record
ord-28db82c8263f48819251724bfb3114e6
Source dataset
uspto-grants-2015_10
Patent number
US09150545B2

Reaction notes

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