Hydrogen Bromide → HCID 68449648, compound

HRID 1747063Notes

Reaction equation

C[O:2][C:3]1[N:8]=[C:7]([CH:9]([NH2:11])[CH3:10])[CH:6]=[CH:5][CH:4]=1.[BrH:12]>>[BrH:12].[NH2:11][CH:9]([C:7]1[NH:8][C:3](=[O:2])[CH:4]=[CH:5][CH:6]=1)[CH3:10]

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 594786346-Methoxy-α-methyl-2-pyridinemethanamine

Product 1

HCID 68449648HCID 68449648, compound

Conditions

Temperature: 80 °C

Procedure

To 1.6 g of 1-(6-methoxypyridin-2-yl)ethanamine was added 23.7 ml of a 47% aqueous hydrobromic acid solution, followed by stirring at 80° C. for 60 hours. After evaporating the solvent under reduced pressure, the residue was washed with diethyl ether to obtain 2.95 g of 6-(1-aminoethyl)pyridin-2(1H)-one hydrobromide as a pale brown solid.

Workup

customAfter evaporating the solvent under reduced pressure
washthe residue was washed with diethyl ether

Sources & evidence

ORD record: ord-17331e8b08434e0ca835fc01a2eb1b37
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09150541B2

Reaction notes

Loading…