反应详情

A solution of the product of Step A (11.07 g, 20.57 mmol, 1 eq) in methanol (60 mL) and solution of HCl in methanol (82 mL of 1.25 M solution, 103 mmol, 5 eq) was heated to 55° C. for 2.5 days. The solution was concentrated to give the product of step B. Calculated for C16H19F3N2O3: 345.1 (M+1). found: 345.3.

1. concentrationThe solution was concentrated