Hydrochloric Acid → HCID 89560341, compound

HRID 1747209Notes

Reaction equation

HRID 1747209 reaction equation
C([NH:8][C@@H:9]([C:18]([OH:20])=[O:19])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([I:17])[CH:12]=1)(OC(C)(C)C)=O.O1CCOCC1.[ClH:27]>>[ClH:27].[NH2:8][C@H:9]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([I:17])[CH:12]=1)[C:18]([OH:20])=[O:19]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 46737391N-(tert-Butoxycarbonyl)-3-iodo-D-phenylalanine

Product 1

HCID 89560341HCID 89560341, compound

Procedure

A solution of Boc-3-iodo-D-phenylalanine (5 g, 12.8 mmol, available from Matrix Scientific and 3BSC) in 4M HCl in dioxane (63.9 mL, 256 mmol) under argon was stirred at RT for 15 h. The resulting suspension was filtered, washed with Et2O and dried in vacuo to give the title compound as a white solid. LC-MS B: tR=0.42 min; [M+H]+=291.98.

Workup

  1. filtrationThe resulting suspension was filtered
  2. washwashed with Et2O
  3. customdried in vacuo

Sources & evidence

ORD record
ord-f5d484d5e4d0467985867773e2cec2ef
Source dataset
uspto-grants-2015_10
Patent number
US09150566B2

Reaction notes

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