Benzene, 1,3-diiodo- → HCID 89560253, compound

HRID 1747235Notes

Reaction equation

HRID 1747235 reaction equation
I[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([I:8])[CH:3]=1.S1(=O)(=O)[N:13]2[CH2:14][CH2:15][CH2:16][C@H:12]2[CH2:11]O1>>[I:8][C:4]1[CH:3]=[C:2]([CH:7]=[CH:6][CH:5]=1)[CH2:11][C@@H:12]1[CH2:16][CH2:15][CH2:14][NH:13]1

Participants

3

Reactant 2

HCID 12270Benzene, 1,3-diiodo-HCID 23255919(3aS)-Tetrahydro-1H,3H-1lambda~6~-pyrrolo[1,2-c][1,2,3]oxathiazole-1,1-dione

Product 1

HCID 89560253HCID 89560253, compound

Procedure

(S)-2-(3-Iodo-benzyl)-pyrrolidine was prepared from 1,3-diiodobenzene and (S)-tetrahydro-pyrrolo[1,2-c][1,2,3]oxathiazole 1,1-dioxide in analogy to the procedure described for Example 4 in U.S. Pat. No. 5,130,432. LC-MS A: tR=0.57 min; [M+H]+=287.99.

Sources & evidence

ORD record
ord-fe884003f5d54b3e87788e7bb2c69122
Source dataset
uspto-grants-2015_10
Patent number
US09150566B2

Reaction notes

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