反应详情

To a solution of 1-isopropenyl-2-benzimidazolinone (2 g, 11.5 mmol) in DMF (10 mL) were added ethyl trans-2-hexenoate (2 g, 14 mmol) and the benzyltrimethylammonium hydroxide (40% in MeOH) (0.4 mL, 2.3 mmol) at room temperature. The solution was heated to 60 C for 12 hours. The solution was cooled down and sat.NH4Cl sol was added. The solution was extracted with EtOAc and the combined organic layer was dried with MgSO4 and filtered. The filtrate was concentrated and the residue was purified by CombiFlash with 20% EtOAc in Hexane to afford the desirable product 3-(3-Isopropenyl-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-hexanoic acid ethyl ester (2 g, 55%) as an colorless oil.

1. customat room temperature
2. temperatureThe solution was heated to 60 C for 12 hours
3. temperatureThe solution was cooled down
4. extractionThe solution was extracted with EtOAc
5. dry with materialthe combined organic layer was dried with MgSO4
6. filtrationfiltered
7. concentrationThe filtrate was concentrated
8. customthe residue was purified by CombiFlash with 20% EtOAc in Hexane