Hydrochloric Acid → HCID 59497263, 화합물

HRID 1747363노트

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HRID 1747363 반응식
[CH2:1]([O:3][C:4](=[O:23])[CH2:5][CH:6]([N:10]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12](C(C)=C)[C:11]1=[O:22])[CH2:7][CH2:8][CH3:9])[CH3:2].Cl>CO>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][CH:6]([N:10]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[NH:12][C:11]1=[O:22])[CH2:7][CH2:8][CH3:9])[CH3:2]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 594976603-(3-Isopropenyl-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-hexanoic acid ethyl ester

생성물 1

HCID 59497263HCID 59497263, 화합물수율 80%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
60 °C

실험 절차

3-(3-Isopropenyl-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-hexanoic acid ethyl ester (1 g, 3.2 mmol) was dissolved in MeOH (30 mL) and HCl (30 mL) solution at room temperature. The solution was heated to 60° C. for 2 hours. The solution was cooled down and was extracted with EtOAc. The combined organic layer was dried with MgSO4 and was filtered. The filtrate was concentrated and the residue was purified by CombiFlash with 5% MeOH in CH2Cl2 as the eluent to afford the desirable product 3-(2-Oxo-2,3-dihydro-benzoimidazol-1-yl)-hexanoic acid ethyl ester (700 mg, 80%) as a colorless oil.

후처리

  1. customat room temperature
  2. temperatureThe solution was cooled down
  3. extractionwas extracted with EtOAc
  4. dry with materialThe combined organic layer was dried with MgSO4
  5. filtrationwas filtered
  6. concentrationThe filtrate was concentrated
  7. customthe residue was purified by CombiFlash with 5% MeOH in CH2Cl2 as the eluent

출처 및 근거

ORD 기록
ord-51bd743b73cc4e00be284ab38cb635cb
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150556B2

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