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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1747374Generated: October 31, 2026

(S)-3-(2-Nitro-phenylamino)-hexanoic acid ethyl ester → (S)-3-(2-Amino-phenylamino)-hexanoic acid ethyl ester

https://huagongshe.com/reaction/1747374

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(S)-3-(2-Nitro-phenylamino)-hexanoic acid ethyl esterHCID 59497566—
CatalystPalladiumHCID 23938—
SolventEthanolHCID 702—
Product(S)-3-(2-Amino-phenylamino)-hexanoic acid ethyl esterHCID 59497425—

Reaction Steps

To a solution of (S)-3-(2-Nitro-phenylamino)-hexanoic acid ethyl ester (795 mg, 2.8 mmol) in EtOH (20 mL) was added Pd/C (10% wt on carbon) (300 mg). The solution was stirred at room temperature for 3 hours. The solution was filtered and the filtrate was concentrated. The residue (683 mg, 96%) was used in the next step of the synthesis without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09150556B2
Source datasetuspto-grants-2015_10
ORD IDord-82ac7aa32dfe417f86dac980a5ae2426
Source noteuspto-grants-2015_10