HCID 59497561, compound → HCID 59497419, compound

HRID 1747379Notes

Reaction equation

HRID 1747379 reaction equation
[C:1]([O:5][C:6](=[O:24])[C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[C:9]([NH:16][CH2:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:8]=1)([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6](=[O:24])[C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[C:9]([NH:16][CH2:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:8]=1)([CH3:3])([CH3:4])[CH3:2]

Participants

4

Reactant 1

HCID 59497561HCID 59497561, compound

Product 1

HCID 59497419HCID 59497419, compoundYield 91.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

3-(2-Ethoxycarbonyl-ethylamino)-4-nitro-benzoic acid tert-butyl ester (1.2 g, 3.55 mmol) was dissolved in ethanol (60 ml) to the solution Pd/C (10%) (300 mg) was added and the reaction mixture was stirred under Hydrogen (1 atmosphere) overnight. The reaction mixture was filtered through celite and evaporated to dryness to give 1 g (91%) of product.

Workup

  1. additionwas added
  2. filtrationThe reaction mixture was filtered through celite
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-48e1335345014e0bb8476d01ed21dd04
Source dataset
uspto-grants-2015_10
Patent number
US09150556B2

Reaction notes

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