HuagongsheHuagongshe Chemistry Print Report · For research reference only
[1-(2-Nitro-phenylamino)-cyclohexyl]-acetic acid methyl ester → [1-(2-Amino-phenylamino)-cyclohexyl]-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [1-(2-Nitro-phenylamino)-cyclohexyl]-acetic acid methyl ester | HCID 59497614 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | [1-(2-Amino-phenylamino)-cyclohexyl]-acetic acid methyl ester | HCID 59497703 | 99% |
Reaction Steps
A mixture of [1-(2-nitro-phenylamino)-cyclohexyl]-acetic acid methyl ester (230 mg, 0.79 mmol), 10% Pd/C (80 mg) in EtOH (20 mL) under H2 atmosphere at room temperature was stirred for 16 h. The reaction mixture was filtered and the organic layer was concentrated to give the desired [1-(2-amino-phenylamino)-cyclohexyl]-acetic acid methyl ester (205 mg, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150556B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-08d2d7a7e0fb4a5eb5b86790c3feb5a5 |
| Source note | uspto-grants-2015_10 |