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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1747409Generated: October 30, 2026

2-Methyl-2-(2-nitro-phenylamino)-propionic acid tert-butyl ester → HCID 59497586, compound

https://huagongshe.com/reaction/1747409

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-2-(2-nitro-phenylamino)-propionic acid tert-butyl esterHCID 59497651—
CatalystPalladiumHCID 23938—
SolventEthanolHCID 702—
ProductHCID 59497586HCID 59497586100%

Reaction Steps

A mixture of 2-methyl-2-(2-nitro-phenylamino)-propionic acid tert-butyl ester (638 mg, 2.3 mmol), 10% Pd/C (110 mg) in EtOH (25 mL) under H2 atmosphere at room temperature was stirred for 30 min. The reaction mixture was filtered and the organic layer was concentrated to give the desired 2-(2-amino-phenylamino)-2-methyl-propionic acid tert-butyl ester (570 mg, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09150556B2
Source datasetuspto-grants-2015_10
ORD IDord-09e0868281784916bad716eda4ebc45d
Source noteuspto-grants-2015_10