反应详情

3-Amino-5-chloro-2-hydroxy-benzoic acid methyl ester 8 g (39.6 mmol) is dissolved in tetrahydrofuran 100 mL and carbonyl diimidazole (12.9 g, 79.3 mmol) is added. The reaction is heated to reflux for 2 hours and then cooled to room temperature. The reaction is evaporated in vacuo and then taken up in dichloromethane (200 mL) and then washed with HCl (2N, 50 mL 2×) and water (2×50 mL). The organic layer is dried (Na2SO4) filtered and evaporated in vacuo to give the title compound (8.2 g, 36 mmol, 91%). LCMS (ESMS): m/z 228.9 (M+H+).

1. temperatureThe reaction is heated
2. temperatureto reflux for 2 hours
3. customThe reaction is evaporated in vacuo
4. washwashed with HCl (2N, 50 mL 2×) and water (2×50 mL)
5. dry with materialThe organic layer is dried (Na2SO4)
6. filtrationfiltered
7. customevaporated in vacuo