HCID 89586350, compound → HCID 89586112, compound

HRID 1747767Notes

Reaction equation

HRID 1747767 reaction equation
[C:1]1([N:7]2[C:11]([C:12]3[C:13](=[O:32])[C:14]4[O:31][CH:30]=[CH:29][C:15]=4[N:16]([C:18]4[CH:23]=[CH:22][C:21]([N:24]5[CH:28]=[CH:27][CH:26]=[N:25]5)=[CH:20][CH:19]=4)[N:17]=3)=[CH:10][CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[Pd].C(O)C>[C:1]1([N:7]2[C:11]([C:12]3[C:13](=[O:32])[C:14]4[O:31][CH2:30][CH2:29][C:15]=4[N:16]([C:18]4[CH:23]=[CH:22][C:21]([N:24]5[CH:28]=[CH:27][CH:26]=[N:25]5)=[CH:20][CH:19]=4)[N:17]=3)=[CH:10][CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 1

HCID 89586350HCID 89586350, compound

Product 1

HCID 89586112HCID 89586112, compoundYield 32.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 3-(1-phenyl-1H-pyrazol-5-yl)-1-[4-(1H-pyrazol-1-yl)phenyl]furo[3,2-c]pyridazin-4(1H)-one (64 mg) and 10% palladium on carbon (100 mg) in ethanol (80 mL) was stirred at 50° C. for 12 hr under a hydrogen atmosphere. Palladium on carbon was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/methanol) to give the title compound (21 mg).

Workup

  1. customPalladium on carbon was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography (ethyl acetate/methanol)

Sources & evidence

ORD record
ord-ead9ba331fe44e1bba976f7895b3ca4a
Source dataset
uspto-grants-2015_10
Patent number
US09150588B2

Reaction notes

Loading…