HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 89586209, compound → HCID 89586214, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 89586209 | HCID 89586209 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 89586214 | HCID 89586214 | 30% |
Reaction Steps
A solution of 6-[(benzyloxy)methyl]-1-(2-tert-butoxyphenyl)-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (0.89 g) in TFA (9 mL) was heated under reflux for 4 hr. After cooling, the solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/methanol) to give the title compound (0.19 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150588B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-545f14e67cb44f7b97c733808a500c2f |
| Source note | uspto-grants-2015_10 |