HCID 89586209, compound → HCID 89586214, compound

HRID 1747772Notes

Reaction equation

HRID 1747772 reaction equation
C([O:8][CH2:9][C:10]1[N:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[O:22]C(C)(C)C)[N:14]=[C:13]([C:27]2[N:31]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[N:30]=[CH:29][CH:28]=2)[C:12](=[O:38])[CH:11]=1)C1C=CC=CC=1>C(O)(C(F)(F)F)=O>[OH:8][CH2:9][C:10]1[N:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[OH:22])[N:14]=[C:13]([C:27]2[N:31]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[N:30]=[CH:29][CH:28]=2)[C:12](=[O:38])[CH:11]=1

Participants

3

Reactant 1

HCID 89586209HCID 89586209, compound

Product 1

HCID 89586214HCID 89586214, compoundYield 30%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 6-[(benzyloxy)methyl]-1-(2-tert-butoxyphenyl)-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (0.89 g) in TFA (9 mL) was heated under reflux for 4 hr. After cooling, the solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/methanol) to give the title compound (0.19 g).

Workup

  1. temperatureunder reflux for 4 hr
  2. temperatureAfter cooling
  3. customthe solvent was evaporated under reduced pressure
  4. customthe residue was purified by silica gel column chromatography (ethyl acetate/methanol)

Sources & evidence

ORD record
ord-545f14e67cb44f7b97c733808a500c2f
Source dataset
uspto-grants-2015_10
Patent number
US09150588B2

Reaction notes

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