反应详情

To a solution of 9-(2-fluorobiphenyl-4-yl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide (200 mg) in THF/methanol (30 mL/30 mL) was added 5% rhodium carbon (50 mg). The reaction mixture was stirred under a hydrogen atmosphere at room temperature for 1 day. Platinum (IV) oxide (40 mg) was added, and the mixture was stirred under a hydrogen atmosphere at room temperature for 9 hr, and insoluble material was filtered off through celite. The filtrate was concentrated under reduced pressure, the obtained residue was purified by recrystallization (THF-ethyl acetate/diisopropyl ether) to give the title compound (121.2 mg).

1. stirringthe mixture was stirred under a hydrogen atmosphere at room temperature for 9 hr
2. filtrationinsoluble material was filtered off through celite
3. concentrationThe filtrate was concentrated under reduced pressure
4. customthe obtained residue was purified by recrystallization (THF-ethyl acetate/diisopropyl ether)