Water → HCID 66748059, compound

HRID 1747911Notes

Reaction equation

HRID 1747911 reaction equation
C(=O)([O-])[O-].[K+].[K+].I[CH2:8][C:9]([CH3:12])([CH3:11])[CH3:10].[O:13]=[S:14]1(=[O:31])[CH2:19][CH2:18][N:17]2[CH:20]=[CH:21][CH:22]=[C:23]([C:24]3[CH:29]=[CH:28][C:27]([OH:30])=[CH:26][CH:25]=3)[C:16]2=[N:15]1.O>CS(C)=O>[CH3:10][C:9]([CH3:12])([CH3:11])[CH2:8][O:30][C:27]1[CH:26]=[CH:25][C:24]([C:23]2[C:16]3=[N:15][S:14](=[O:31])(=[O:13])[CH2:19][CH2:18][N:17]3[CH:20]=[CH:21][CH:22]=2)=[CH:29][CH:28]=1

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 84953Propane, 1-iodo-2,2-dimethyl-HCID 667478174-(2,2-Dioxido-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazin-9-yl)phenol

Product 1

HCID 66748059HCID 66748059, compoundYield 72.6%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
150 °C

Procedure

A mixture of potassium carbonate (300 mg), 1-iodo-2,2-dimethylpropane (430 mg) and 4-(2,2-dioxido-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazin-9-yl)phenol (200 mg) in DMSO (5 mL) was stirred at 150° C. for 1 hr. Water was added to give a precipitate. The precipitate was collected by filtration and washed with Et2O-water. The precipitate was crystallized from CH3CN-IPE to give the title compound (182 mg) as a white solid.

Workup

  1. customto give a precipitate
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with Et2O-water
  4. customThe precipitate was crystallized from CH3CN-IPE

Sources & evidence

ORD record
ord-fc49888c1dc24046987b8ed9988164f1
Source dataset
uspto-grants-2015_10
Patent number
US09150591B2

Reaction notes

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