HCID 66748670, compound → HCID 66748669, compound

HRID 1748047Notes

Reaction equation

HRID 1748047 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:14]3=[N:15][S:16](=[O:20])(=[O:19])[CH2:17][CH2:18][N:13]3[CH:12]=[CH:11][CH:10]=2)=[CH:5][CH:4]=1>CO.[Pt](=O)=O>[F:22][C:2]([F:1])([F:21])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[C:14]3=[N:15][S:16](=[O:19])(=[O:20])[CH2:17][CH2:18][N:13]3[CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1

Participants

4

Reactant 1

HCID 66748670HCID 66748670, compound

Product 1

HCID 66748669HCID 66748669, compoundYield 26.9%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 887MethanolSolvent

Procedure

A mixture of 9-[4-(trifluoromethyl)phenyl]-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide (250 mg) and platinum(IV) oxide (25.9 mg) in MeOH (10 mL) was stirred at room temperature under H2 for 20 hr. The reaction mixture was filtered by Celite and the filtrate was concentrated in vacuo. The residue was recrystallized from EtOAc-MeOH to give the title compound (68.0 mg) as a white solid.

Workup

  1. filtrationThe reaction mixture was filtered by Celite
  2. concentrationthe filtrate was concentrated in vacuo
  3. customThe residue was recrystallized from EtOAc-MeOH

Sources & evidence

ORD record
ord-28253f3bc63b4a1cb1b1ffe4ccce9533
Source dataset
uspto-grants-2015_10
Patent number
US09150591B2

Reaction notes

Loading…