Hydrochloric Acid → HCID 66823991, compound

HRID 1748079Notes

Reaction equation

HRID 1748079 reaction equation
[Si]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C@@H:15]2[C:20]3=[N:21][S:22](=[O:26])(=[O:25])[CH2:23][CH2:24][N:19]3[CH2:18][CH2:17][CH2:16]2)=[CH:11][CH:10]=1)(C(C)(C)C)(C)C.Cl>CO>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([C@@H:15]2[C:20]3=[N:21][S:22](=[O:26])(=[O:25])[CH2:23][CH2:24][N:19]3[CH2:18][CH2:17][CH2:16]2)=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66748472HCID 66748472, compound

Product 1

HCID 66823991HCID 66823991, compoundYield 95.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of (9R)-9-(4-((tert-butyldimethylsilyl)oxy)phenyl)-3,4,6,7,8,9-hexahydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide (11.8 g) and 6 M HCl aq. (15.0 mL) in MeOH (100 mL) was stirred at 60° C. for 2 hr. After cooling to room temperature, the precipitate was collected and washed with MeOH to give the title compound (8.04 g) as a white solid.

Workup

  1. temperatureAfter cooling to room temperature
  2. customthe precipitate was collected
  3. washwashed with MeOH

Sources & evidence

ORD record
ord-37e2fc2baa1742dfad5f7e86c57f69e8
Source dataset
uspto-grants-2015_10
Patent number
US09150591B2

Reaction notes

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