HCID 66748903, compound → HCID 66748082, compound

HRID 1748136Notes

Reaction equation

HRID 1748136 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[C:16]([NH2:21])=[N:17][CH:18]=[CH:19][CH:20]=2)=[CH:11][C:10]=1[F:22])C1C=CC=CC=1>CCO.[Pt](=O)=O>[NH2:21][C:16]1[C:15]([C:12]2[CH:13]=[CH:14][C:9]([OH:8])=[C:10]([F:22])[CH:11]=2)=[CH:20][CH:19]=[CH:18][N:17]=1

Participants

4

Reactant 1

HCID 66748903HCID 66748903, compound

Product 1

HCID 66748082HCID 66748082, compoundYield 54.3%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent

Procedure

A mixture of 3-(4-(benzyloxy)-3-fluorophenyl)pyridin-2-amine (8.5 g), and platinum(IV) oxide (400 mg) in EtOH (200 mL) was stirred at room temperature under hydrogen overweekend. The mixture was added with NH silica gel, concentrated in vacuo, and purified by column chromatography (NH silica gel, eluted with MeOH in EtQAc) to give the title compound (3.20 g) as a pale yellow solid.

Workup

  1. additionThe mixture was added with NH silica gel
  2. concentrationconcentrated in vacuo
  3. custompurified by column chromatography (NH silica gel, eluted with MeOH in EtQAc)

Sources & evidence

ORD record
ord-14996c84c49849d18d5b65716be90550
Source dataset
uspto-grants-2015_10
Patent number
US09150591B2

Reaction notes

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