Sodium Carbonate → HCID 86704399, compound

HRID 1748159Notes

Reaction equation

HRID 1748159 reaction equation
[C:1]1([C@@H:7]2[CH2:9][C@H:8]2[CH:10]=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:13][OH:14].C([O-])([O-])=O.[Na+].[Na+]>CCO>[C:1]1([C@@H:7]2[CH2:9][C@H:8]2[CH:10]=[N:13][OH:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 12323031Cyclopropanecarboxaldehyde, 2-phenyl-, (1R,2R)- (9CI)

Product 1

HCID 86704399HCID 86704399, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of trans-2-phenylcyclopropanecarbaldehyde rac-I-6B (0.89 g, 6.1 mmol) in EtOH (12 mL) and cooled to 0°C. was treated with hydroxylamine hydrochloride (0.43 g, 6.1 mmol) and Na2CO3. The reaction mixture was allowed to warm to rt and stir fo(12 h. The volatiles were removed in vacuo and extracted with EtOAc. The organics were collected, dried over Na2SO4 filtered, and concentrated to afford trans-2-Phenylcyclopropanecarbaldehyde oxime which was used without further purification.

Workup

  1. custom12 h
  2. customThe volatiles were removed in vacuo
  3. extractionextracted with EtOAc
  4. customThe organics were collected
  5. dry with materialdried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-75082b188efe404ab772fae131ae0968
Source dataset
uspto-grants-2015_10
Patent number
US09150568B2

Reaction notes

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