反应详情

A solution of 6-((Benzyloxy)methyl)-1,4-dioxaspiro[4.5]decane (2.4 g 9.1 mmol) in acetone (40 mL) was treated with 1.5N HCl (18 mL) and stirred at rt for 5 hours. The reaction mixture was neutralized with aqueous sodium carbonate and the volatile removed in vacuo. The residue was extracted with Et2O (3×50 mL) and the combined organic layer were washed with water (30 mL), brine (30 mL) and dried over sodium sulfate and concentrated to yield the desired product as pale yellow oil that was used in the next step without further purification. MS m/z 219.1 (M+1).

1. customthe volatile removed in vacuo
2. extractionThe residue was extracted with Et2O (3×50 mL)
3. washthe combined organic layer were washed with water (30 mL), brine (30 mL)
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated