Methanol → Methyl 2-hydroxypyrrolo[1,2-b]pyridazine-6-carboxylate

HRID 1748196Notes

Reaction equation

HRID 1748196 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([OH:13])=[O:12])[CH:10]=2)[N:7]=1.[CH3:14]O>S(=O)(=O)(O)O>[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:10]=2)[N:7]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 178524046HCID 178524046, compound

Product 1

HCID 178496938Methyl 2-hydroxypyrrolo[1,2-b]pyridazine-6-carboxylate

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidCatalyst

Conditions

Temperature
80 °C

Procedure

The semi-crude material from above, 2-Hydroxypyrrolo[1,2-b]pyridazine-6-carboxylic acid (100 mg, 0.56 mmol) was dissolved in methanol (5 mL) and concentrated sulfuric acid (2 drops). The solution was heated to 80° C. for 4 hours, and then the solvent evaporated in vacuo. The crude material was used directly in the next step. MS m/z 193.1 (M+1).

Workup

  1. customthe solvent evaporated in vacuo

Sources & evidence

ORD record
ord-a4ca24f32e1547ada81293a2e03aeead
Source dataset
uspto-grants-2015_10
Patent number
US09150568B2

Reaction notes

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