反应详情

温度

65 °C

To a suspension of ethyl 4,4-dimethyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-7-carboxylate (2.7 g, 9.3 mmol) in methanol (30 mL) is added 3N NaOH solution (15.5 mL, 46.5 mmol). The reaction mixture is heated at 65° C. for 16 h. The reaction mixture is diluted with water and acidified to pH 2 using 2N HCl solution at 0° C. The resulting white solid is filtered, rinsed with water and dried to afford the title compound (2.1 g, 88%) as a white solid.

1. customat 0° C
2. filtrationThe resulting white solid is filtered
3. washrinsed with water
4. customdried