Hydrochloric Acid → HCID 58767565, compound

HRID 1748254Notes

Reaction equation

HRID 1748254 reaction equation
[CH3:1][C:2]1([CH3:21])[N:7]2[C:8]3[CH:9]=[C:10]([C:15]([O:17]CC)=[O:16])[CH:11]=[CH:12][C:13]=3[CH:14]=[C:6]2[C:5](=[O:20])[NH:4][CH2:3]1.[OH-].[Na+].Cl>CO.O>[CH3:1][C:2]1([CH3:21])[N:7]2[C:8]3[CH:9]=[C:10]([C:15]([OH:17])=[O:16])[CH:11]=[CH:12][C:13]=3[CH:14]=[C:6]2[C:5](=[O:20])[NH:4][CH2:3]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58767572HCID 58767572, compound

Product 1

HCID 58767565HCID 58767565, compoundYield 88%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
65 °C

Procedure

To a suspension of ethyl 4,4-dimethyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-7-carboxylate (2.7 g, 9.3 mmol) in methanol (30 mL) is added 3N NaOH solution (15.5 mL, 46.5 mmol). The reaction mixture is heated at 65° C. for 16 h. The reaction mixture is diluted with water and acidified to pH 2 using 2N HCl solution at 0° C. The resulting white solid is filtered, rinsed with water and dried to afford the title compound (2.1 g, 88%) as a white solid.

Workup

  1. customat 0° C
  2. filtrationThe resulting white solid is filtered
  3. washrinsed with water
  4. customdried

Sources & evidence

ORD record
ord-a79799cf81554fc283d9ed442d657d2d
Source dataset
uspto-grants-2015_10
Patent number
US09150577B2

Reaction notes

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