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HRID1748261

反应详情

EQUATION

反应方程式

HRID 1748261 的结构方程式

REACTANTS

反应物

2
结构：CC(C)O
HCID3776

Isopropanol

C3H8O

结构：C[C@@H]1NC(=O)c2cc3ccc(C(=O)O)cc3n2[C@@H]1C
HCID67234926

未命名化合物

2 次

PRODUCTS

生成物

2
结构：CCOC(=O)c1ccc2cc3n(c2c1)[C@@H](C)[C@@H](C)NC3=O
HCID67234919

未命名化合物

收率 45%
结构：CCOC(=O)c1ccc2cc3n(c2c1)[C@H](C)[C@H](C)NC3=O
HCID67235475

未命名化合物

收率 46%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCCCCCC
溶剂HCID8900

Heptane

C7H16

PROCEDURE

实验过程

Racemic cis-3,4-dimethyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-7-carboxylic acid (Intermediate F, 1.9 g, 6.7 mmol) is separated on a preparative chiral column (Chiralpak AD, 5 cm×50 cm, 20 u, Chiral Technologies, West Chester, Pa.) using Gilson preparative HPLC (Mobile Phase: 12% isopropanol in heptane; Flow rate: 100 mL/min) to afford ethyl (3S,4R)-3,4-dimethyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-7-carboxylate (870 mg, 46%) and ethyl (3R,4S)-3,4-dimethyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-7-carboxylate (852 mg, 45%).