Sodium Hydroxide → HCID 178510736, compound

HRID 1748316Notes

Reaction equation

HRID 1748316 reaction equation
[OH-:1].[Na+].Cl.[NH2:4]O.[C:6]1([C:12]2([CH2:17][C:18]#[N:19])[O:16][CH2:15][CH2:14][O:13]2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>CO>[OH:1][NH:19][C:18](=[NH:4])[CH2:17][C:12]1([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=2)[O:16][CH2:15][CH2:14][O:13]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 3525985HCID 3525985, compound

Product 1

HCID 178510736HCID 178510736, compoundYield 85.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Sodium hydroxide (3.1 g, 77 mmol) is added to hydroxylamine hydrochloride (5.2 g, 75 mmol) at 0° C. and is stirred for 15 min. A solution of (2-phenyl-1,3-dioxolan-2-yl)acetonitrile (7 g, 37 mmol) in methanol (25 mL) is added dropwise to the reaction mixture at 0° C. The reaction mixture is allowed to warm to room temperature and is heated at 90° C. for 16 h. The solvent was evaporated under reduced pressure to afford the title compound as a brown solid (7 g, 85%) which is used in the next step without purification.

Workup

  1. temperatureis heated at 90° C. for 16 h
  2. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-dd78f62eaa754636b2b725d4d7c29e9e
Source dataset
uspto-grants-2015_10
Patent number
US09150577B2

Reaction notes

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