反应详情

温度

120 °C

To a mixture of ethyl[(3,3-dimethyl-2-oxobutyl)amino](oxo)acetate (40 g, 162 mmol) in toluene (350 mL) is added phosphorous oxychloride (75 g, 488 mmol). The reaction mixture is heated at 120° C. for 14 h. Then the solvent is removed and the residue is diluted with ether. The ether layer is washed with saturated aqueous NaHCO3 solution, brine, dried (Na2SO4) and concentrated to afford the title compound (28 g, 87%).

1. customThen the solvent is removed
2. additionthe residue is diluted with ether
3. washThe ether layer is washed with saturated aqueous NaHCO3 solution, brine
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated