Potassium Carbonate → HCID 86682398, compound

HRID 1748340Notes

Reaction equation

HRID 1748340 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:14])[C:10]([F:13])([F:12])[F:11])=[C:4]([CH2:15][N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)[CH:3]=1.[N+:22]([O-])([O-:24])=[O:23].[K+].C([O-])([O-])=O.[K+].[K+]>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:7]=[C:6]([N+:22]([O-:24])=[O:23])[C:5]([NH:8][C:9](=[O:14])[C:10]([F:13])([F:11])[F:12])=[C:4]([CH2:15][N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)[CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 24434Potassium NitrateHCID 86682397HCID 86682397, compound

Product 1

HCID 86682398HCID 86682398, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Conditions

Temperature
0 °C

Procedure

To a mixture of N-[4-chloro-2-(morpholin-4-ylmethyl)phenyl]-2,2,2-trifluoroacetamide (3.8 g, 11.8 mmol) in concentrated sulfuric acid (35 mL) cooled to 0° C. is added potassium nitrate (1.4 g, 14.1 mmol). The reaction is slowly warmed to room temperature over a period of 2 h and is then poured into ice water. The mixture is neutralized with saturated aqueous K2CO3 and the resulting solid is isolated by filtration to afford the title compound (3.6 g, 82%).

Workup

  1. temperatureThe reaction is slowly warmed to room temperature over a period of 2 h
  2. customthe resulting solid is isolated by filtration

Sources & evidence

ORD record
ord-3c8204d832e14f898ce5806a22a5939e
Source dataset
uspto-grants-2015_10
Patent number
US09150577B2

Reaction notes

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