反应详情

温度

60 °C

A suspension of ethyl 4-{[(4,4-dimethyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indol-7-yl)carbonyl]amino}-1-methyl-1H-imidazole-2-carboxylate (540 mg, 1.3 mmol) in 3N NaOH solution (2.2 mL, 6.6 mmol) and methanol (5 mL) is heated at 60° C. for 2 h. The mixture is acidified with 2N HCl solution until the pH is about 2. The solution is allowed to cool with stifling. After 2 h the resulting solid is collected by filtration, washed with water and dried to afford the title compound (350 mg, 70%).

1. temperatureto cool
2. filtrationAfter 2 h the resulting solid is collected by filtration
3. washwashed with water
4. customdried