Hydrazine hydrate (1:1) → HCID 16495384, compound

HRID 1748428Notes

Reaction equation

HRID 1748428 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][N:3]=1.O.[NH2:13][NH2:14]>C(O)C>[ClH:1].[F:9][C:8]([F:11])([F:10])[C:5]1[CH:6]=[CH:7][C:2]([NH:13][NH2:14])=[N:3][CH:4]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 923422-Chloro-5-(trifluoromethyl)pyridine

Product 1

HCID 16495384HCID 16495384, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

2-Chloro-5-(trifluoromethyl)pyridine (25 g) and hydrazine monohydrate (100%) (100 ml) were added to ethanol (60 ml) and stirred at 100° C. for three hours. The reaction solution was concentrated in vacuo, chloroform and water were added to the residue, the organic layer was separated and dried over anhydrous sodium sulfate. The solvent was exaporated in vacuo and 4N hydrochloric acid ethanol solution was added to the residue to give 5-trifluoromethylpyridin-2-ylhydrazine hydrochloride (15.4 g).

Workup

  1. concentrationThe reaction solution was concentrated in vacuo, chloroform and water
  2. additionwere added to the residue
  3. customthe organic layer was separated
  4. dry with materialdried over anhydrous sodium sulfate
  5. additionwas added to the residue

Sources & evidence

ORD record
ord-67f863934ba144eb92e6712aa34b36a6
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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