Hydrazine hydrate (1:1) → 3,5-Dichloro-2-hydrazinylpyridine

HRID 1748432Notes

Reaction equation

HRID 1748432 reaction equation
Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([Cl:9])=[CH:4][N:3]=1.O.[NH2:11][NH2:12]>C(O)C>[Cl:8][C:7]1[C:2]([NH:11][NH2:12])=[N:3][CH:4]=[C:5]([Cl:9])[CH:6]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 27666Pyridine, 2,3,5-trichloro-

Product 1

HCID 6009663,5-Dichloro-2-hydrazinylpyridineYield 98.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

2,3,5-Trichloropyridine (25 g) and hydrazine monohydrate (109.8 g) were added to ethanol (20 ml), stirred at 100° C. and left to stand at room temperature. The precipitated solid was collected by filtration to give 3,5-dichloropyridin-2-ylhydrazine (24.07 g).

Workup

  1. waitleft
  2. customto stand at room temperature
  3. filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-db4ed7d204624588bd7b598714824623
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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