Ethanol → 5-Bromo-2-hydrazinopyridine

HRID 1748435Notes

Reaction equation

HRID 1748435 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[N:6][CH:7]=1.O.[NH2:10][NH2:11].C(O)C>O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:10][NH2:11])=[N:6][CH:7]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 27831685-Bromo-2-fluoropyridine

Product 1

HCID 115356995-Bromo-2-hydrazinopyridineYield 94.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5-Bromo-2-fluoropyridine (25.12 g) and hydrazine monohydrate (100%) (91 g) were added to ethanol (75 ml), stirred under reflux for four hours, and then water was added thereto and the precipitated solid was washed with water to give 5-bromopyridin-2-ylhydrazine (25.3 g) as a white solid.

Workup

  1. temperatureunder reflux for four hours
  2. washthe precipitated solid was washed with water

Sources & evidence

ORD record
ord-3ab339dec5244c6c9ae5762a6d7c6f93
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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