Sodium Hydroxide → HCID 86692423, compound

HRID 1748452Notes

Reaction equation

HRID 1748452 reaction equation
[OH-].[Na+].C([O:5][C:6]([C:8]1[CH:9]=[N:10][N:11]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][O:21][CH3:22])=[CH:16][CH:15]=2)[C:12]=1[CH3:13])=[O:7])C>C(O)C>[CH3:22][O:21][CH2:20][C:17]1[CH:16]=[CH:15][C:14]([N:11]2[C:12]([CH3:13])=[C:8]([C:6]([OH:7])=[O:5])[CH:9]=[N:10]2)=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86692422HCID 86692422, compound

Product 1

HCID 86692423HCID 86692423, compoundYield 87.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Conditions

Temperature
70 °C

Procedure

1N Aqueous solution of sodium hydroxide (7.0 ml) was added at room temperature to a solution of 1-[4-(methoxymethyl)phenyl]-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (401 mg) in ethanol (14 ml) and stirred at 70° C. for two hours. After completion of the reaction, ethanol was evaporated, water and 1N hydrochloric acid aqueous solution was added therein and the precipitated solid was collected by filtration to give the titled compound (314 mg) as a white solid.

Workup

  1. customwas evaporated
  2. additionwater and 1N hydrochloric acid aqueous solution was added
  3. filtrationthe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-dbea9b9b9b7b4f949b6c5eb4911c6b78
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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