Hydrochloric Acid → HCID 86692426, compound

HRID 1748457Notes

Reaction equation

HRID 1748457 reaction equation
[OH-].[Na+].C([O:5][C:6]([C:8]1[CH:9]=[N:10][N:11]([C:14]2[CH:19]=[CH:18][C:17]([CH:20]([F:22])[F:21])=[CH:16][CH:15]=2)[C:12]=1[CH3:13])=[O:7])C.Cl>C(O)C>[F:22][CH:20]([F:21])[C:17]1[CH:16]=[CH:15][C:14]([N:11]2[C:12]([CH3:13])=[C:8]([C:6]([OH:7])=[O:5])[CH:9]=[N:10]2)=[CH:19][CH:18]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86692427HCID 86692427, compound

Product 1

HCID 86692426HCID 86692426, compoundYield 90.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2N Aqueous solution of sodium hydroxide (32 ml) was added to a solution of 1-[4-(difluoromethyl)phenyl]-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (1.8 g) in ethanol (32 ml) at room temperature and stirred at the same temperature for 12 hours. After completion of the reaction, 1N hydrochloric acid aqueous solution was added and the precipitated solid was filtered to give the titled compound (1.46 g) as a white solid.

Workup

  1. additionwas added
  2. filtrationthe precipitated solid was filtered

Sources & evidence

ORD record
ord-27af76a0279b4bd98a0326ac1ba47cf7
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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