Hydrochloric Acid → HCID 86692431, compound

HRID 1748461Notes

Reaction equation

HRID 1748461 reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([C:12]2[C:13]([Cl:20])=[N:14][CH:15]=[C:16]([CH2:18][CH3:19])[CH:17]=2)[C:10]=1[CH3:11])=[O:5])C.[OH-].[Na+].C(O)C.Cl>O>[Cl:20][C:13]1[C:12]([N:9]2[C:10]([CH3:11])=[C:6]([C:4]([OH:5])=[O:3])[CH:7]=[N:8]2)=[CH:17][C:16]([CH2:18][CH3:19])=[CH:15][N:14]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 86692430HCID 86692430, compound

Product 1

HCID 86692431HCID 86692431, compoundYield 84.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-(2-Chloro-5-ethylpyridin-3-yl)-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (0.639 g) and 4N aqueous solution of sodium hydroxide (5 ml) were added to a mixed solvent of ethanol (10 ml) and water (5 ml) and stirred at room temperature for an hour. The reaction solution was cooled to 0° C., 1N hydrochloric acid aqueous solution (30 ml) was added dropwise and the precipitated solid was filtered to give the titled compound (0.488 g).

Workup

  1. temperatureThe reaction solution was cooled to 0° C.
  2. filtrationthe precipitated solid was filtered

Sources & evidence

ORD record
ord-4613cd1962424b9c94564b3e286c5412
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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