Water → HCID 53402978, compound

HRID 1748462Notes

Reaction equation

HRID 1748462 reaction equation
O.[NH2:2][NH2:3].[Br:4][C:5]1[CH:6]=[C:7]([Cl:12])[C:8](Cl)=[N:9][CH:10]=1.O>C(O)C>[Br:4][C:5]1[CH:6]=[C:7]([Cl:12])[C:8]([NH:2][NH2:3])=[N:9][CH:10]=1

Participants

5

Reactant 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 127477605-Bromo-2,3-dichloropyridine

Product 1

HCID 53402978HCID 53402978, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrazine monohydrate (50 ml) was stirred at 100° C., a solution of 5-bromo-2,3-dichloropyridine (15.0 g) in ethanol (25 ml) was added therein dropwise over an hour and the mixture was stirred at the same temperature. After completion of the reaction, the reaction solution was cooled to room temperature, water (150 ml) was added and stirred at the room temperature. The precipitated solid was collected by filtration to give (5-bromo-3-chloropyridin-2-yl)hydrazine (14.78 g) as a white solid.

Workup

  1. waitdropwise over an hour
  2. customAfter completion of the reaction
  3. stirringstirred at the room temperature
  4. filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-891097fd8fa24f28bb039081c52a9c10
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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