Hydrochloric Acid → HCID 86692433, compound

HRID 1748464Notes

Reaction equation

HRID 1748464 reaction equation
O.[OH-].[Na+].C([O:6][C:7]([C:9]1[CH:10]=[N:11][N:12]([C:15]2[C:20]([Cl:21])=[CH:19][C:18]([Br:22])=[CH:17][N:16]=2)[C:13]=1[CH3:14])=[O:8])C.Cl>C(O)C>[Br:22][C:18]1[CH:19]=[C:20]([Cl:21])[C:15]([N:12]2[C:13]([CH3:14])=[C:9]([C:7]([OH:8])=[O:6])[CH:10]=[N:11]2)=[N:16][CH:17]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 86692432HCID 86692432, compound

Product 1

HCID 86692433HCID 86692433, compoundYield 78,707.602%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

Water (7 ml) and 4N aqueous solution of sodium hydroxide (7 ml) were added at room temperature to a solution of 1-(5-bromo-3-chloropyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (1.00 mg) in ethanol (14 ml) and stirred at 80° C. for five hours. After completion of the reaction, the reaction solution was cooled to 0° C. and 1N hydrochloric acid aqueous solution (29 ml) was added. The precipitated solid was collected by filtration to give the titled compound (723 mg) as a light brown solid.

Workup

  1. customAfter completion of the reaction
  2. temperaturethe reaction solution was cooled to 0° C.
  3. filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-5753933bb489475f945ce4a22ae13499
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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