Hydrochloric Acid → HCID 86692441, compound

HRID 1748473Notes

Reaction equation

HRID 1748473 reaction equation
[OH-].[Na+].C([O:5][C:6]([C:8]1[CH:9]=[N:10][N:11]([C:14]2[C:19]([Cl:20])=[CH:18][C:17]([CH2:21][CH3:22])=[CH:16][N:15]=2)[C:12]=1[CH3:13])=[O:7])C.Cl>O>[Cl:20][C:19]1[C:14]([N:11]2[C:12]([CH3:13])=[C:8]([C:6]([OH:7])=[O:5])[CH:9]=[N:10]2)=[N:15][CH:16]=[C:17]([CH2:21][CH3:22])[CH:18]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86692439HCID 86692439, compound

Product 1

HCID 86692441HCID 86692441, compoundYield 76.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Water (4 ml) and 4N aqueous solution of sodium hydroxide (4 ml) were added at room temperature to a solution of 1-(3-chloro-5-ethylpyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (454 mg), and stirred at room temperature for 15 hours. After completion of the reaction, the reaction solution was cooled to 0° C. and 1N hydrochloric acid aqueous solution was added. The precipitated solid was collected by filtration to give the titled compound (314 mg) as a white solid.

Workup

  1. customAfter completion of the reaction
  2. temperaturethe reaction solution was cooled to 0° C.
  3. filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-864fa00d99ac44fd92b3fba49b86e1e6
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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