Hydrochloric Acid → HCID 19624584, compound

HRID 1748475Notes

Reaction equation

HRID 1748475 reaction equation
O.[OH-].[Na+].C([O:6][C:7]([C:9]1[CH:10]=[N:11][N:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][N:15]=2)[CH:13]=1)=[O:8])C.Cl>C(O)C>[F:23][C:20]([F:21])([F:22])[C:17]1[CH:18]=[CH:19][C:14]([N:12]2[CH:13]=[C:9]([C:7]([OH:8])=[O:6])[CH:10]=[N:11]2)=[N:15][CH:16]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 81504459HCID 81504459, compound

Product 1

HCID 19624584HCID 19624584, compoundYield 72.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

Water (5 ml) and 4N aqueous solution of sodium hydroxide (5 ml) were added at room temperature to a solution of 1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (544 mg) in ethanol (10 ml), and stirred at 80° C. for 3.5 hours. After completion of the reaction, the reaction solution was cooled to 0° C. and 1N hydrochloric acid aqueous solution (21 ml) was added. The precipitated solid was collected by filtration to give the titled compound (356 mg) as a white solid.

Workup

  1. customAfter completion of the reaction
  2. temperaturethe reaction solution was cooled to 0° C.
  3. filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-4518cf0f85df4b54b95ffdaa9222255c
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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