Water → 3-Chloro-2-hydrazinyl-5-(trifluoromethyl)pyridine

Participants

Reaction Steps

To a solution of 2,3-dichloro-5-(trifluoromethyl)pyridine (25 g) in ethanol (75 ml) was added hydrazine hydrate (100%) (16.9 ml) at room temperature, and stirred. After completion of the reaction, water was added thereto, the organic solvent was evaporated in vacuo, the precipitated solid was collected by filtration, and washed with water to give 3-chloro-5-(trifluoromethyl)pyridin-2-ylhydrazine (24 g) as a white solid.

Provenance & Evidence