Water → 3-Chloro-2-hydrazinyl-5-(trifluoromethyl)pyridine

HRID 1748545Notes

Reaction equation

HRID 1748545 reaction equation
Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][N:3]=1.O.[NH2:14][NH2:15].O>C(O)C>[Cl:8][C:7]1[C:2]([NH:14][NH2:15])=[N:3][CH:4]=[C:5]([C:9]([F:12])([F:11])[F:10])[CH:6]=1

Participants

5

Reactant 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 1122342,3-Dichloro-5-(trifluoromethyl)pyridine

Product 1

HCID 12726913-Chloro-2-hydrazinyl-5-(trifluoromethyl)pyridine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2,3-dichloro-5-(trifluoromethyl)pyridine (25 g) in ethanol (75 ml) was added hydrazine hydrate (100%) (16.9 ml) at room temperature, and stirred. After completion of the reaction, water was added thereto, the organic solvent was evaporated in vacuo, the precipitated solid was collected by filtration, and washed with water to give 3-chloro-5-(trifluoromethyl)pyridin-2-ylhydrazine (24 g) as a white solid.

Workup

  1. additionwas added
  2. customthe organic solvent was evaporated in vacuo
  3. filtrationthe precipitated solid was collected by filtration
  4. washwashed with water

Sources & evidence

ORD record
ord-da024b57d3c24c978879e80867c26135
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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