HCID 16794101, compound → HCID 86692527, compound

HRID 1748577Notes

Reaction equation

HRID 1748577 reaction equation
Br[C:2]1[CH:3]=[C:4]([F:20])[C:5]([C:8]2[CH2:13][CH2:12][CH:11]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)[CH2:10][CH:9]=2)=[N:6][CH:7]=1.CC1C(C(O)=O)=C(C)N(C2C=CC(C(F)(F)F)=CN=2)[N:23]=1>>[F:20][C:4]1[CH:3]=[C:2]([NH2:23])[CH:7]=[N:6][C:5]=1[C:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[CH2:10][CH:9]=1

Participants

3

Reactant 2

HCID 16794101HCID 16794101, compoundHCID 86692528HCID 86692528, compound

Product 1

HCID 86692527HCID 86692527, compound

Procedure

4-[4-(5-Bromo-3-fluoropyridin-2-yl)cyclohex-3-en-1-yl]morpholine (2.28 g) was used in place of 1-(5-bromopyridin-2-yl)-c-4-(tert-butyldimethyl silanyloxy)-r-1-cyclohexanecarbonitrile in Reference Example 144 (2) and (3), and reacted and treated in a similar manner to give the titled compound (1.68 g) as a pale yellow solid. MS (ESI) m/z: 278 (M+H)+.

Workup

  1. customreacted
  2. additiontreated in a similar manner

Sources & evidence

ORD record
ord-f82bea6294644355b99734bf36fd2b91
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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