HCID 16794101, compound → HCID 178455310, compound

HRID 1748578Notes

Reaction equation

HRID 1748578 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([C@H:8]2[CH2:13][CH2:12][C@H:11]([O:14][Si:15]([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:17])[CH3:16])[CH2:10][CH2:9]2)=[N:6][CH:7]=1.CC1C(C(O)=O)=C(C)N(C2C=CC(C(F)(F)F)=CN=2)[N:24]=1>>[Si:15]([O:14][C@H:11]1[CH2:12][CH2:13][C@H:8]([C:5]2[N:6]=[CH:7][C:2]([NH2:24])=[CH:3][CH:4]=2)[CH2:9][CH2:10]1)([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 16794101HCID 16794101, compoundHCID 178455308HCID 178455308, compound

Product 1

HCID 178455310HCID 178455310, compound

Procedure

trans-5-Bromo-2-[4-(tert-butyldimethylsilyloxy)cyclohex-1-yl]pyridine (1.54 g) described in Reference Example 103 (3) was used in place of 1-(5-bromopyridin-2-yl)-c-4-(tert-butyldimethylsilanyloxy)-r-1-cyclohexanecarbonitrile in Reference Example 144 (2) and (3), and reacted and treated in a similar manner to give the titled compound (1.11 g) as a white solid.

Workup

  1. customreacted
  2. additiontreated in a similar manner

Sources & evidence

ORD record
ord-5c0118ecbb4f4808b495d0f3aad4f9d8
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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