HCID 16794101, compound → HCID 86692533, compound

HRID 1748581Notes

Reaction equation

HRID 1748581 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([C:8]2([OH:18])[CH2:17][CH2:16][C:11]3([O:15][CH2:14][CH2:13][O:12]3)[CH2:10][CH2:9]2)=[N:6][CH:7]=1.CC1C(C(O)=O)=C(C)N(C2C=CC(C(F)(F)F)=CN=2)[N:21]=1>>[NH2:21][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([OH:18])[CH2:17][CH2:16][C:11]3([O:15][CH2:14][CH2:13][O:12]3)[CH2:10][CH2:9]2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 16794101HCID 16794101, compoundHCID 57803252HCID 57803252, compound

Product 1

HCID 86692533HCID 86692533, compound

Procedure

8-(5-Bromopyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol (3.0 g) described in Reference Example 76 (1) was used in place of 1-(5-bromopyridin-2-yl)-c-4-(tert-butyldimethylsilanyloxy)-r-1-cyclohexanecarbonitrile in Reference Example 144 (2) and (3), and reacted and treated in a similar manner to give the titled compound (1.28 g) as a white solid.

Workup

  1. customreacted
  2. additiontreated in a similar manner

Sources & evidence

ORD record
ord-dbcb282dea4045029335808c6acbe28e
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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