Hydrochloric Acid → HCID 178524793, compound

HRID 1748609Notes

Reaction equation

HRID 1748609 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)[NH:9][CH:10]=1)=[O:5])C.[OH-].[Na+].Cl>CO>[F:20][C:17]([F:18])([F:19])[C:14]1[CH:13]=[CH:12][C:11]([C:8]2[NH:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178469886HCID 178469886, compound

Product 1

HCID 178524793HCID 178524793, compoundYield 52.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 2-[4-(trifluoromethyl)phenyl]-1H-imidazole-4-carboxylic acid ethyl ester (300 mg) in methanol (4 ml) was added 1 N aqueous solution of sodium hydroxide (4 ml) at room temperature, and stirred at 80° C. for 6.5 hours. After completion of the reaction, 1 N hydrochloric acid aqueous solution (4 ml) was added thereto, and the solvent was evaporated. The obtained residue was washed with water, and dried in vacuo to give the titled compound (141 mg) as a pale brown solid.

Workup

  1. additionwas added
  2. customthe solvent was evaporated
  3. washThe obtained residue was washed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-b10cbc925cd8469486d82a45db29a867
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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