Methanesulfonic Acid → HCID 86692564, compound

HRID 1748622Notes

Reaction equation

HRID 1748622 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH:6]1([C:9]2[CH:10]=[CH:11][C:12]([N:15]3[C:19]([CH3:20])=[C:18]([C:21]([NH:23][C:24]4[CH:25]=[N:26][C:27]([C:30]5[CH2:35][CH2:34][CH:33]([N:36]6[CH2:41][CH2:40][O:39][CH2:38][CH2:37]6)[CH2:32][CH:31]=5)=[CH:28][CH:29]=4)=[O:22])[CH:17]=[N:16]3)=[N:13][CH:14]=2)[CH2:8][CH2:7]1>C(Cl)(Cl)Cl.CO>[S:2]([OH:5])(=[O:4])(=[O:3])[CH3:1].[CH:6]1([C:9]2[CH:10]=[CH:11][C:12]([N:15]3[C:19]([CH3:20])=[C:18]([C:21]([NH:23][C:24]4[CH:25]=[N:26][C:27]([C:30]5[CH2:35][CH2:34][CH:33]([N:36]6[CH2:41][CH2:40][O:39][CH2:38][CH2:37]6)[CH2:32][CH:31]=5)=[CH:28][CH:29]=4)=[O:22])[CH:17]=[N:16]3)=[N:13][CH:14]=2)[CH2:8][CH2:7]1

Participants

5

Reactant 2

HCID 6395Methanesulfonic AcidHCID 56961762HCID 56961762, compound

Product 1

HCID 86692564HCID 86692564, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6212ChloroformSolvent

Procedure

Methanesulfonic acid (47 μl) was added at room temperature to a solution of 1-(5-cyclopropylpyridin-2-yl)-5-methyl-N-{6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1H-pyrazole-4-carboxamide (315 mg) in chloroform (6.3 ml) and methanol (0.7 ml) and stirred at the same temperature for 12 hours. After the reaction, the solvent was evaporated, ethyl acetate was added to the resulting residue and the precipitated solid was filtered to give the titled compound (340 mg) as a white solid.

Workup

  1. customAfter the reaction
  2. customthe solvent was evaporated
  3. additionethyl acetate was added to the resulting residue
  4. filtrationthe precipitated solid was filtered

Sources & evidence

ORD record
ord-4da8366259c04c46a55375ad33ad5ee0
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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