HCID 86692579, compound → HCID 86692578, compound

HRID 1748640Notes

Reaction equation

HRID 1748640 reaction equation
O1[C:5]2([CH2:10][CH2:9][CH:8]([C:11]3[N:16]=[CH:15][C:14]([NH:17][C:18]([C:20]4[CH:21]=[N:22][N:23]([C:26]5[C:31]([F:32])=[CH:30][C:29]([C:33]([F:36])([F:35])[F:34])=[CH:28][N:27]=5)[C:24]=4[CH3:25])=[O:19])=[CH:13][C:12]=3[CH3:37])[CH2:7][CH2:6]2)[O:4]CC1.C(C1(C2N=CC(NC(C3C=C(C)N(C4C=CC(C(F)(F)F)=CN=4)N=3)=O)=CC=2)CCC2(OCCO2)CC1)#N>>[F:32][C:31]1[C:26]([N:23]2[C:24]([CH3:25])=[C:20]([C:18]([NH:17][C:14]3[CH:15]=[N:16][C:11]([CH:8]4[CH2:9][CH2:10][C:5](=[O:4])[CH2:6][CH2:7]4)=[C:12]([CH3:37])[CH:13]=3)=[O:19])[CH:21]=[N:22]2)=[N:27][CH:28]=[C:29]([C:33]([F:34])([F:36])[F:35])[CH:30]=1

Participants

3

Reactant 2

HCID 86692579HCID 86692579, compoundHCID 86692580HCID 86692580, compound

Product 1

HCID 86692578HCID 86692578, compoundYield 94.5%

Procedure

N-[6-(1,4-Dioxaspiro[4.5]dec-8-yl)-5-methylpyridin-3-yl]-1-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]-5-methyl-1H-pyrazole-4-carboxamide (274 mg) described in Example D196 was used in place of N-[6-(8-cyano-1,4-dioxaspiro[4.5]dec-8-yl)pyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazolecarboxamide in Example F2(1), and reacted and treated in a similar manner to give the titled compound (237 mg).

Workup

  1. customreacted
  2. additiontreated in a similar manner

Sources & evidence

ORD record
ord-dbbf3cdd09b14425a58afa2e942105ae
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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